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Reissue of RFA-FD-22-001 - Efficient and Innovative Natural History Studies Addressing Unmet Needs in Rare Diseases (R01 Clinical Trials Optional)

Food and Drug Administration

NEXARA Match editorial contextOriginal provider and source attribution is preserved.

The purpose of this notice of funding opportunity (NOFO) is to support efficient and innovative natural history studies that advance medical product development in rare diseases/conditions with unmet needs. Through the support of natural history studies with high quality and…

Reissue of RFA-FD-22-001 - Efficient and Innovative Natural History Studies Addressing Unmet Needs in Rare Diseases (R01 Clinical Trials Optional) visual
NEXARA Match opportunity visualNEXARA Match editorial view
USDeadline Feb 8, 2028

About this opportunity

The purpose of this notice of funding opportunity (NOFO) is to support efficient and innovative natural history studies that advance medical product development in rare diseases/conditions with unmet needs.

Through the support of natural history studies with high quality and interpretable data elements, FDA expects to address critical knowledge gaps, remove major barriers to progress in the field, exert a significant and broad impact on a specific rare disease or multiple rare diseases with similar pathophysiology, and facilitate rare disease product development.

NEXARA decision support

NEXARA application brief for this grants

NEXARA's decision-support view of this grants focuses on whether the practical conditions match your profile before you invest time in an application. The listed location is US. No compensation or funding amount is clearly recorded in the structured listing. Deadline Feb 8, 2028; plan your own working deadline earlier than the official close.

Eligibility first

No structured mandatory requirement is recorded here. That does not mean there are no eligibility rules; review the full official notice before applying.

Evidence to prepare

No mandatory document list is recorded in the structured data. Check the official application portal for CV, transcript, identity, reference or proposal requirements.

Fit beyond the title

The listing does not expose mandatory skills in a structured form. Compare the responsibilities and selection criteria with specific examples from your experience.

Final source check

Before submission, confirm the deadline, eligibility, application route and any fees directly with Grants.gov. NEXARA keeps source attribution visible, but the provider's current instructions remain authoritative for the application itself.

Questions to answer before you apply

  • Is there a nationality, residency or work-authorisation restriction that affects you?
  • If the opportunity is abroad, do you already have the required right to study or work there?
  • Which two or three pieces of evidence best demonstrate that you meet the mandatory criteria?
  • What must be requested from another person or institution before the deadline?
  • Is the official application page consistent with the information shown here today?

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